We have inherited from our forefathers the keen longing for unified, all-embracing knowledge. The very name given to the highest institutions of learning reminds us, that from antiquity to and throughout many centuries the universal aspect has been the only one to be given full credit. But the spread, both in and width and depth, of the multifarious branches of knowledge by during the last hundred odd years has confronted us with a queer dilemma. We feel clearly that we are only now beginning to acquire reliable material for welding together the sum total of all that is known into a whole; but, on the other hand, it has become next to impossible for a single mind fully to command more than a small specialized portion of it. I can see no other escape from this dilemma (lest our true who aim be lost for ever) than that some of us should venture to embark on a synthesis of facts and theories, albeit with second-hand and incomplete knowledge of some of them -and at the risk of making fools of ourselves.
What is Life? (pdf)
First published 1944
This book ultimately inspired Watson and his contemporaries to search for a molecular theory of inheritance.